Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses
T Tsuchiya, PEH Schwarz, L del Bosque-Plata… - Molecular genetics and …, 2006 - Elsevier
We conducted pooled and meta-analyses of the association of the calpain-10 gene
(CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes
with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the
pooled analyses, the common SNP-43* G allele was associated with modest but statistically
significant increased risk of T2D (odds ratio (OR)= 1.11 (95% confidence interval (CI), 1.02–
1.20), P= 0.01). Two haplotype combinations were associated with increased risk of T2D (1 …
(CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes
with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the
pooled analyses, the common SNP-43* G allele was associated with modest but statistically
significant increased risk of T2D (odds ratio (OR)= 1.11 (95% confidence interval (CI), 1.02–
1.20), P= 0.01). Two haplotype combinations were associated with increased risk of T2D (1 …