The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors: a …
The geranylgeranyltransferase I inhibitor GGTI-298 has recently been shown to arrest
human tumor cells in the G 1 phase of the cell cycle, induce apoptosis, and inhibit tumor
growth in nude mice. In the present manuscript, we provide a possible mechanism by which
GGTI-298 mediates its tumor growth arrest. Treatment of the human lung carcinoma cell line
Calu-1 with GGTI-298 results in inhibition of the phosphorylation of retinoblastoma protein, a
critical step for G 1/S transition. The kinase activities of two G 1/S cyclin-dependent kinases …
human tumor cells in the G 1 phase of the cell cycle, induce apoptosis, and inhibit tumor
growth in nude mice. In the present manuscript, we provide a possible mechanism by which
GGTI-298 mediates its tumor growth arrest. Treatment of the human lung carcinoma cell line
Calu-1 with GGTI-298 results in inhibition of the phosphorylation of retinoblastoma protein, a
critical step for G 1/S transition. The kinase activities of two G 1/S cyclin-dependent kinases …
