Immunomodulation of the melanoma sentinel lymph node: a novel adjuvant therapeutic option
BG Molenkamp, PAM van Leeuwen… - Immunobiology, 2006 - Elsevier
Cutaneous melanoma is the most aggressive type of skin cancer. Paradoxically, melanoma
is also the most immunogenic tumour identified to date: tumour-reactive T cells are
detectable both in the blood and in tumour-draining lymph nodes (TDLN) of melanoma
patients and their frequency can be increased by specific vaccination. However, early
melanoma development is accompanied by impaired immune effector functions in the initial
TDLN, the sentinel lymph node (SLN). Most notably, a reduced frequency and activation …
is also the most immunogenic tumour identified to date: tumour-reactive T cells are
detectable both in the blood and in tumour-draining lymph nodes (TDLN) of melanoma
patients and their frequency can be increased by specific vaccination. However, early
melanoma development is accompanied by impaired immune effector functions in the initial
TDLN, the sentinel lymph node (SLN). Most notably, a reduced frequency and activation …