Targeting the double-strand DNA break repair pathway as a therapeutic strategy
CJ Lord, MD Garrett, A Ashworth - Clinical cancer research, 2006 - AACR
CJ Lord, MD Garrett, A Ashworth
Clinical cancer research, 2006•AACRDNA repair pathways are crucial for the maintenance of genome integrity. The pathway that
repairs DNA double-strand breaks (DSB) has components involved in both signaling and
repairing DNA damage. Impairing DSB repair using specific inhibitors of signaling or repair
might, in principle, sensitize tumor cells to particular DNA-damaging agents. Moreover, the
existence of specific defects in DNA repair pathways in tumors provides the rationale for the
use of “synthetic lethal” approaches targeting this cellular “Achilles' heel.” Here, we discuss …
repairs DNA double-strand breaks (DSB) has components involved in both signaling and
repairing DNA damage. Impairing DSB repair using specific inhibitors of signaling or repair
might, in principle, sensitize tumor cells to particular DNA-damaging agents. Moreover, the
existence of specific defects in DNA repair pathways in tumors provides the rationale for the
use of “synthetic lethal” approaches targeting this cellular “Achilles' heel.” Here, we discuss …
Abstract
DNA repair pathways are crucial for the maintenance of genome integrity. The pathway that repairs DNA double-strand breaks (DSB) has components involved in both signaling and repairing DNA damage. Impairing DSB repair using specific inhibitors of signaling or repair might, in principle, sensitize tumor cells to particular DNA-damaging agents. Moreover, the existence of specific defects in DNA repair pathways in tumors provides the rationale for the use of “synthetic lethal” approaches targeting this cellular “Achilles' heel.” Here, we discuss the mechanisms involved in DSB repair and detail potential therapeutic approaches based on targeting this pathway.
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