Dendritic cells (DCs) consist of a heterogeneous collection of subsets, many with unique
phenotypic and functional characteristics. Although certain subsets migrate from peripheral
non-lymphoid tissues, there is evidence that antigen presentation can extend to DCs that
permanently reside within the lymph node. This Opinion describes this finding in the context
of antigen transfer between migrating and lymphoid-resident DCs in cases of T-cell priming
and tolerance induction.