CD4+ CD25+ suppressor lymphocytes in the circulation of patients immunized against melanoma antigens
LR Javia, SA Rosenberg - Journal of Immunotherapy, 2003 - journals.lww.com
Murine studies have suggested that a population of CD4+ T cells expressing the alpha chain
of the interleukin (IL)-2 receptor (CD25+) are phenotypically anergic in response to T cell
receptor stimulation and can suppress the function of CD4+ and CD8+ T cells. Recent
studies of peripheral lymphocytes from healthy human volunteers have identified a similar
population, although little is known about the presence and activity of these cells in patients
with cancer and their possible impact on anticancer immunization strategies. Thus, the …
of the interleukin (IL)-2 receptor (CD25+) are phenotypically anergic in response to T cell
receptor stimulation and can suppress the function of CD4+ and CD8+ T cells. Recent
studies of peripheral lymphocytes from healthy human volunteers have identified a similar
population, although little is known about the presence and activity of these cells in patients
with cancer and their possible impact on anticancer immunization strategies. Thus, the …