[HTML][HTML] SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling
The suppressor of cytokine signaling-3 (SOCS3/CIS3) has been shown to be an important
negative regulator of cytokines, especially cytokines that activate STAT3. To examine the
role of SOCS3 in neutrophils and the granulocyte colony-stimulating factor (G-CSF)
signaling in vivo, we compared neutrophils from two types of conditional knockout mice,
LysM-Cre: SOCS3 fl/fl mice and Tie2-Cre: SOCS3 fl/fl mice, in which the Socs3 gene had
been deleted in mature neutrophils and hematopoietic stem cells, respectively. The size of …
negative regulator of cytokines, especially cytokines that activate STAT3. To examine the
role of SOCS3 in neutrophils and the granulocyte colony-stimulating factor (G-CSF)
signaling in vivo, we compared neutrophils from two types of conditional knockout mice,
LysM-Cre: SOCS3 fl/fl mice and Tie2-Cre: SOCS3 fl/fl mice, in which the Socs3 gene had
been deleted in mature neutrophils and hematopoietic stem cells, respectively. The size of …