Calmodulin kinase and L-type calcium channels: A recipe for arrhythmias?
ME Anderson - Trends in cardiovascular medicine, 2004 - Elsevier
L-type Ca2+ channels (LTCCs) are the main portal for Ca2+ entry into cardiac myocytes.
These ion channel proteins open in response to cell membrane depolarizations elicited by
action potentials, and LTCC current (ICa) flows during the action potential plateau, to
increase cellular Ca2+ (Ca2+ i) and trigger myocardial contraction. ICais also implicated in
the genesis of cardiac arrhythmias under conditions such as heart failure and cardiac
hypertrophy, in which the action potential plateau and QT interval are prolonged. This article …
These ion channel proteins open in response to cell membrane depolarizations elicited by
action potentials, and LTCC current (ICa) flows during the action potential plateau, to
increase cellular Ca2+ (Ca2+ i) and trigger myocardial contraction. ICais also implicated in
the genesis of cardiac arrhythmias under conditions such as heart failure and cardiac
hypertrophy, in which the action potential plateau and QT interval are prolonged. This article …