Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation
K Sayama, Y Hanakawa, Y Shirakata… - Journal of Biological …, 2001 - ASBMB
Cells differentiate in response to various extracellular stimuli. This cellular response requires
intracellular signaling pathways. The mitogen-activated protein (MAP) kinase cascade is a
core signal transduction pathway that determines the fate of many kinds of cell. MAP kinase
kinase kinase activates MAP kinase kinase, which in turn activates MAP kinase. Apoptosis
signal-regulating kinase (ASK1) was identified as a MAP kinase kinase kinase involved in
the stress-induced apoptosis-signaling cascade that activates the SEK1-JNK and …
intracellular signaling pathways. The mitogen-activated protein (MAP) kinase cascade is a
core signal transduction pathway that determines the fate of many kinds of cell. MAP kinase
kinase kinase activates MAP kinase kinase, which in turn activates MAP kinase. Apoptosis
signal-regulating kinase (ASK1) was identified as a MAP kinase kinase kinase involved in
the stress-induced apoptosis-signaling cascade that activates the SEK1-JNK and …