Nitration and inactivation of tyrosine hydroxylase by peroxynitrite
B Blanchard-Fillion, JM Souza, T Friel… - Journal of Biological …, 2001 - ASBMB
Tyrosine hydroxylase (TH) is modified by nitration after exposure of mice to 1-methyl-4-
phenyl-1, 2, 3, 6-tetrahydrophenylpyridine. The temporal association of tyrosine nitration
with inactivation of TH activityin vitro suggests that this covalent post-translational
modification is responsible for the in vivo loss of TH function (Ara, J., Przedborski, S., Naini,
AB, Jackson-Lewis, V., Trifiletti, RR, Horwitz, J., and Ischiropoulos, H.(1998) Proc. Natl.
Acad. Sci. USA 95, 7659–7663). Recent data showed that cysteine oxidation rather than …
phenyl-1, 2, 3, 6-tetrahydrophenylpyridine. The temporal association of tyrosine nitration
with inactivation of TH activityin vitro suggests that this covalent post-translational
modification is responsible for the in vivo loss of TH function (Ara, J., Przedborski, S., Naini,
AB, Jackson-Lewis, V., Trifiletti, RR, Horwitz, J., and Ischiropoulos, H.(1998) Proc. Natl.
Acad. Sci. USA 95, 7659–7663). Recent data showed that cysteine oxidation rather than …
