The relative contribution of adduct blockage and DNA repair on template utilization during replication of 1, N2-propanodeoxyguanosine and pyrimido [1, 2-α] purin-10 …
SP Fink, LJ Marnett - Mutation Research/DNA Repair, 2001 - Elsevier
The role of replication blockage by the exocyclic DNA adducts propanodeoxyguanosine
(PdG) and pyrimido [1, 2-α] purin-10 (3H)-one (M1G) was determined through the use of site-
specifically adducted M13MB102 genomes containing a C: C-mismatch∼ 3000 base-pairs
from the site of adduct incorporation. Genomes containing either dG, PdG, or M1G
positioned at site 6256 of the (−)-strand were transformed into repair-proficient and repair-
deficient Escherichia coli strains and the percent template utilization was determined by …
(PdG) and pyrimido [1, 2-α] purin-10 (3H)-one (M1G) was determined through the use of site-
specifically adducted M13MB102 genomes containing a C: C-mismatch∼ 3000 base-pairs
from the site of adduct incorporation. Genomes containing either dG, PdG, or M1G
positioned at site 6256 of the (−)-strand were transformed into repair-proficient and repair-
deficient Escherichia coli strains and the percent template utilization was determined by …
